Articles
The science & research behind ketamine therapy.
The science around ketamine therapy is moving fast. Every study brings new insights into how this treatment can support people facing conditions like depression, anxiety, PTSD, chronic pain and more.
This section brings together a selection of research and articles that shed light on the evolving conversation around ketamine treatment. Whether you’re looking to understand the science more deeply or are simply curious about the direction treatment is moving in, we aim to help you feel more confident as you explore options.
- ARTICLE:
Ketamine for generalised Anxiety Disorder
This was a double-blind, psychoactive-controlled ascending dose study in 12 patients with treatment-resistant generalized anxiety and social anxiety disorders who were not currently depressed. Ascending doses of ketamine (0.25, 0.5, 1 mg/kg) were administered at weekly intervals, and midazolam 0.01 mg/kg, the control, was...
- ARTICLE:
Ketamine for Social Anxiety Disorder
Many patients with social anxiety disorder (SAD) experience inadequate symptom relief from available treatments. This double-blind, randomised, placebo-controlled crossover trial has 18 adults participants and compares the effects between intravenous ketamine (0.5 mg/kg over 40 min) and placebo (normal saline) on social...
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Ketamine Administration for Chronic Post-traumatic Stress Disorder
Post traumatic stress disorder (PTSD) is a chronic and disabling disorder, for which available pharmacotherapies have limited efficacy. The authors’ previous proof-of-concept randomized controlled trial of single-dose intravenous ketamine infusion in individuals with PTSD showed significant and rapid PTSD symptom...
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Ketamine Effects on EEG during Therapy of Treatment-Resistant Generalised Anxiety and Social Anxiety
Ketamine is swiftly effective in a range of neurotic disorders that are resistant to conventional antidepressant and anxiolytic drugs. The neural basis for its therapeutic action is unknown. Here we report the effects of ketamine on the EEG of patients with treatment-resistant generalized anxiety and social anxiety disorders.
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Safety and efficacy of maintenance ketamine treatment in patients with treatment-refractory generalised anxiety and social anxiety disorders
The effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders are explored
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Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder
The effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders are explored
- ARTICLE:
Randomised Controlled Crossover Trial of Ketamine in Obsessive-CompulsiveDisorder: Proof-of-Concept
Serotonin re-uptake inhibitors (SRIs), the first-line pharmacological treatment for obsessive-compulsive disorder (OCD), have two limitations: incomplete symptom relief and 2-3 months lag time before clinically meaningful improvement. New medications with faster onset are needed. As converging evidence suggests a role...
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Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine asadjunctive therapy in treatment-resistant depression
Numerous placebo-controlled studies have demonstrated the ability of ketamine, an NMDA receptor antagonist, to induce rapid (within hours), transient antidepressant effects when administered intravenously (IV) at subanesthetic doses (0.5 mg/kg over 40 min). However, the optimal antidepressant dose remains unknown...
- ARTICLE:
Ketamine Reduces Alcohol Consumption in Hazardous Drinkers by Interfering with the Reconsolidation of Drinking Memories
Maladaptive reward memories (MRMs) are involved in the development and maintenance of acquired overconsumption disorders, such as harmful alcohol and drug use. The process of memory reconsolidation - where stored memories become briefly labile upon retrieval - may offer a means to disrupt MRMs and prevent...
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A sub-set of psychoactive effects may be critical to the behavioural impact of Ketamine on cocaine use disorder
Efforts to translate sub-anesthetic ketamine infusions into widespread clinical use have centered around developing medications with comparable neurobiological activity, but with attenuated psychoactive effects so as to minimize the risk of behavioral toxicity and abuse liability. Converging lines of research, however, suggest...
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Ketamine psychotherapy for heroin addiction: immediate effects and two-year follow-Up
Seventy detoxified heroin-addicted patients were randomly assigned to one of two groups receiving ketamine psychotherapy (KPT) involving two different doses of ketamine. The patients of the experimental group received existentially oriented psychotherapy in combination with a hallucinogenic (“psychedelic”) dose of ketamine...
- ARTICLE:
Efficacy of Ketamine in the Treatment of Substance Use Disorders: A Systematic Review
Despite advances in behavioral and pharmacotherapy interventions, substance use disorders (SUDs) are frequently refractory to treatment. Glutamatergic dysregulation has received increasing attention as one common neuropathology across multiple substances of abuse. Ketamine is a potent N-methyl-D-aspartate (NMDA)...
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Remission from Chronic Anorexia Nervosa With Ketogenic Diet and KetamineSource: National Library of Medicine
Chronic anorexia nervosa is a tragic disease with no known effective pharmacological or behavioral treatment. We report the case of a 29 year-old woman who struggled with severe and enduring anorexia nervosa for 15 years, and experienced a complete recovery following a novel treatment of adopting a ketogenic...